The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor.

@article{Plaschke2012TheII,
  title={The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor.},
  author={Konstanze Plaschke and Franziska Bent and Claudia Rosenhagen and Soeren Wagner and Stefan Hofer and J{\"u}rgen Kopitz},
  journal={Coronary artery disease},
  year={2012},
  volume={23 3},
  pages={215-20}
}
OBJECTIVE Levosimendan enhances cardiac contractility by increasing myocyte sensitivity to calcium and causing vasodilatation. Although studies have evaluated the efficacy of levosimendan in heart failure, whether levosimendan produces an effect on platelets is a subject of controversy. In the present study, the in-vitro effect of levosimendan on platelet… CONTINUE READING