The inhibitory effects of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide on osteoclast formation are associated with upregulation of osteoprotegerin and downregulation of RANKL and RANK.

@article{Mukohyama2000TheIE,
  title={The inhibitory effects of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide on osteoclast formation are associated with upregulation of osteoprotegerin and downregulation of RANKL and RANK.},
  author={Hitoshi Mukohyama and Maria Ransj{\"o} and Hiroshi Taniguchi and Takayuki Ohyama and Ulf H. Lerner},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={271 1},
  pages={158-63}
}
The presence of a network of peptidergic nerve fibers in the skeleton, expressing several neuropeptides including vasoactive intestinal peptide (VIP), has been demonstrated. This observation, together with our findings in vitro showing that VIP can regulate the activities of osteoblasts and osteoclasts as well as the recruitment of osteoclasts, has suggested the existence of a neuro-osteogenic interplay in bone metabolism. In the present study, the effects of VIP and pituitary adenylate cyclase… CONTINUE READING

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