The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters.

@article{Xu2013TheIE,
  title={The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters.},
  author={Fei Xu and Zhen Li and Jian Zheng and Florence Shin Gee Cheung and Ting Fai Chan and Ling Zhu and Hongxiang Zhuge and Fanfan Zhou},
  journal={Journal of pharmaceutical sciences},
  year={2013},
  volume={102 11},
  pages={4205-11}
}
Solute carrier transporters (SLCs), in particular the organic anion transporters (OATs), OAT polypeptides (OATPs), and organic cation transporters (OCTs/OCTNs), are the important membrane proteins responsible for the cellular influx of various drugs. Baicalein (BA), baicalin (BG), and wogonin (WG) are the three major bioactive components of Scutellaria baicalensis. In this study, we evaluated the inhibitory effects of BA, BG, and WG on the cellular uptake of specific substrates mediated by the… CONTINUE READING