The inhibitory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on human colon cancer cells.

@article{Qiu2011TheIE,
  title={The inhibitory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on human colon cancer cells.},
  author={Peiju Qiu and Hua-shi Guan and Ping Dong and Shan-Shan Guo and Jinkai Zheng and Shiming Li and Yun Chen and Chitang Ho and Min-Hsiung Pan and David Julian McClements and H. G. Xiao},
  journal={Molecular nutrition & food research},
  year={2011},
  volume={55 10},
  pages={1523-32}
}
SCOPE Previously, we reported that 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), a polymethoxyflavone found in citrus peels, potently inhibited the growth of multiple human colon cancer cells. Herein, we further investigated the anti-cancer mechanisms of 5HHMF in human colon cancer cells. METHODS AND RESULTS Colony formation assay revealed that 5HHMF dose dependently inhibited colony formation of multiple colon cancer cells. Western blot analysis demonstrated 5HHMF decreased nuclear… CONTINUE READING