The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity.

  title={The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity.},
  author={Basilia Zingarelli and Garry J. Southan and Eli Gilad and Margaret P O'Connor and Andrew L. Salzman and Csaba Szab{\'o}},
  journal={British journal of pharmacology},
  volume={120 3},
1. It has been proposed that in inflammatory conditions, in which both the inducible isoforms of nitric oxide synthase (iNOS) and cyclo-oxygenase (COX-2) are induced, inhibition of NOS also results in inhibition of arachidonic acid metabolism. In the present study we have investigated whether mercaptoalkylguanidines, a novel class of selective iNOS inhibitors, may also influence the activity of cyclo-oxygenase (COX). Therefore, the effect of mercaptoethylguanidine (MEG) and related compounds on… CONTINUE READING
17 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…