The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes

@article{Siebert2011TheIE,
  title={The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes},
  author={Justin R Siebert and Donna J Osterhout},
  journal={Journal of Neurochemistry},
  year={2011},
  volume={119}
}
J. Neurochem. (2011) 119, 176–188. 
The Role of Extracellular Matrix in Myelination and Oligodendrogenesis of the Central Nervous System
*Corresponding Author: Sajad Sahab Negah E-mail: sahabnegahs@mums.ac.ir
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination
TLDR
Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS lesions and the functional roles of CSPGs on oligodendrocyte precursor cells (OPCs), oligodendedrocytes, and remyelination are examined.
Keratan Sulfate Proteoglycans in Plasticity and Recovery after Spinal Cord Injury
The limited potential for regeneration and plasticity of adult mammalian CNS axons is a major impediment to functional recovery following spinal cord injury (SCI). Inhibitory extracellular matrix,
Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair
TLDR
The role of C SPGs as inhibitors, the role of inflammation in stimulating CSPG expression near site of injury, and therapeutic strategies for overcoming the inhibitory effects of CSPGs and creating an environment conducive to nerve regeneration are discussed.
An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
TLDR
It is shown that in vitro, OPCs have dramatically reduced process outgrowth in the presence of CSPGs, and a medication library that includes a number of recently reported OPC differentiation drugs failed to rescue this inhibitory phenotype on CSPG.
Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9
TLDR
It is reported that glial cells in demyelinating lesions show increased expression of fibroblast growth factor 9, which induces astrocyte-dependent responses that inhibit remyelination and stimulate expression of pro-inflammatory chemokines, supporting a feedback loop that amplifies disease activity.
2‐arachidonoylglycerol reduces chondroitin sulphate proteoglycan production by astrocytes and enhances oligodendrocyte differentiation under inhibitory conditions
TLDR
Overall, the data obtained favor targeting the endocannabinoid system to neutralize CSPG accumulation and to enhance oligodendrocyte differentiation.
Chondroitin sulfate proteoglycans inhibit the migration and differentiation of oligodendrocyte precursor cells and its counteractive interaction with laminin
TLDR
The present study has revealed a potential novel therapeutic target for WMI in premature infants, and identified β1-integrin signaling as a pathological mechanism for dysfunctional myelination in white matter.
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TLDR
This review focuses on a discussion of the expression, characterization and modulation of individual astrocytic PGs and the role that astrocyclic PGs play in both the development and pathophysiology of the nervous system.
PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
TLDR
It is shown that a transmembrane protein tyrosine phosphatase, PTPσ, binds with high affinity to neural CSPGs and may provide new therapeutic approaches to neural regeneration.
Regeneration beyond the glial scar
TLDR
Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.
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