The inhibitory effect of thioproline on carcinogenesis induced by N-benzylmethylamine and nitrite.

@article{Tahira1988TheIE,
  title={The inhibitory effect of thioproline on carcinogenesis induced by N-benzylmethylamine and nitrite.},
  author={T. Tahira and H. Ohgaki and K. Wakabayashi and M. Nagao and T. Sugimura},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1988},
  volume={26 6},
  pages={
          511-6
        }
}
  • T. Tahira, H. Ohgaki, +2 authors T. Sugimura
  • Published 1988
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • Thioproline, which is readily nitrosated to form nitrosothioproline, is expected to act as a nitrite scavenger. The effect of thioproline as an inhibitor of the carcinogenesis induced by N-nitroso-N-benzylmethylamine precursors was examined. Two groups of male F-344 rats were given diet containing 0.25% N-benzylmethylamine (group I) or 0.25% N-benzylmethylamine plus thioproline (0.25% until wk 17 and then 0.5%; group II). Both groups were given drinking-water containing sodium nitrite (0.1… CONTINUE READING
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