The inhibitory effect of proanthocyanidin on soluble and collagen-bound proteases.

@article{Epasinghe2013TheIE,
  title={The inhibitory effect of proanthocyanidin on soluble and collagen-bound proteases.},
  author={Don Jeevanie Epasinghe and Cynthia Kar Yung Yiu and Michael F Burrow and Noriko Hiraishi and Franklin R Tay},
  journal={Journal of dentistry},
  year={2013},
  volume={41 9},
  pages={832-9}
}
OBJECTIVE This study evaluated the inhibitory effect of proanthocyanidin (PA), a natural collagen cross-linker, on soluble and matrix-bound proteases, which are responsible for progressive degradation of exposed collagen fibrils within the hybrid layer and resin-dentine bond failure over time. METHODS The inhibitory effects of PA (1%, 2%, 3%, 4.5% and 6%) on soluble recombinant matrix metalloproteinases (MMP-2, -8 and -9) and cysteine cathepsins (cathepsin B and K) were evaluated using MMP… CONTINUE READING
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