Corpus ID: 21628472

The inhibitory effect of methotrexate on PAF-induced neutrophil and eosinophil locomotion in asthmatic patients.

@article{Tsai1994TheIE,
  title={The inhibitory effect of methotrexate on PAF-induced neutrophil and eosinophil locomotion in asthmatic patients.},
  author={J. J. Tsai and T. F. Wang and S. Wang},
  journal={Asian Pacific journal of allergy and immunology},
  year={1994},
  volume={12 1},
  pages={
          65-71
        }
}
  • J. J. Tsai, T. F. Wang, S. Wang
  • Published 1994
  • Medicine
  • Asian Pacific journal of allergy and immunology
  • We have tested the effect of methotrexate (MTX) on platelet activating factor (PAF)-induced neutrophil and eosinophil locomotion, neutrophil leukotriene B4 (LTB4) generation and mononuclear cell DNA synthesis. Neutrophils from patients treated with low dose methotrexate showed reduced PAF-induced chemotactic responses (727.8 +/- 72.2/10 HPF vs 481.9 +/- 87.3/10 HPF, p < 0.05). Both MTX and the specific PAF antagonist BN-52021 significantly inhibited PAF-induced eosinophil and neutrophil… CONTINUE READING

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