The inhibitory effect of intracerebroventricularly injected interleukin 1beta on testosterone secretion in the rat: role of steroidogenic acute regulatory protein.

@article{Ogilvie1999TheIE,
  title={The inhibitory effect of intracerebroventricularly injected interleukin 1beta on testosterone secretion in the rat: role of steroidogenic acute regulatory protein.},
  author={Katheen M Ogilvie and K Held Hales and Michael E Roberts and Dale Buchanan Hales and Catherine Rivier},
  journal={Biology of reproduction},
  year={1999},
  volume={60 2},
  pages={527-33}
}
Exposure to disease or injury often results in impaired reproductive activity accompanied by decreased testosterone levels. After immune activation, the cytokine interleukin 1-beta (IL-1beta) circulates in high concentrations, and its exogenous administration evokes many of the sequelae of immune activation. Previously, we have shown that the administration of this cytokine into the cerebral ventricles blunts hCG-stimulated testosterone secretion. This effect, though time-dependent, occurs… CONTINUE READING