The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-1.

  title={The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-1.},
  author={Asha Jacob and Derry Rajan and Betsy Pathickal and Imran Balouch and Adam Hartman and Rongqian Wu and Mian Zhou and Ping Wang},
  journal={International journal of molecular medicine},
  volume={25 1},
Hepatocellular dysfunction occurs early in sepsis and this appears to be caused by Kupffer cell-derived TNF-alpha production from the liver as a result of the increased release of the sympathetic neurotransmitter, norepinephrine, from the gut. Ghrelin, a novel stomach-derived peptide, is down-regulated in sepsis and administration of ghrelin into rodents decrease pro-inflammatory cytokines, attenuates hepatic and other organ injuries and improves survival. Ghrelin's beneficial effect in sepsis… 

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