The inhibitory effect of genistein on the growth and metastasis of a transplantable rat accessory sex gland carcinoma.

@article{Schleicher1999TheIE,
  title={The inhibitory effect of genistein on the growth and metastasis of a transplantable rat accessory sex gland carcinoma.},
  author={Rosemary L. Schleicher and Coral A. Lamartiniere and Mengjie Zheng and Mengwen Zhang},
  journal={Cancer letters},
  year={1999},
  volume={136 2},
  pages={195-201}
}
BACKGROUND A cell line (K1) derived from a carcinogen-induced accessory sex gland carcinoma was used to examine the effects of the soybean extract, genistein, on tumor growth and metastasis. METHODS Male Lobund-Wistar rats were injected s.c. with 20 million K1 cells; genistein (50 mg/kg BW) or the vehicle was administered s.c. every 12 h for 31 days. RESULTS Genistein significantly inhibited tumor growth. Compared with controls, fewer genistein-treated rats developed invasive tumors (11% vs… CONTINUE READING

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