The inhibitory effect of gallamine on muscarinic receptors.

  title={The inhibitory effect of gallamine on muscarinic receptors.},
  author={Andy Clark and Fred Mitchelson},
  journal={British journal of pharmacology},
  volume={58 3},
1 The inhibitory effect of gallamine (1.1 muM-1.1 mM) on negative inotropic responses to acetylcholine (ACh) or carbachol (CCh) was investigated in isolated electrically stimulated atria of the guinea-pig. Gallamine caused parallel rightward shifts of the dose-response curves to the agonists, with no depression of the maximal response. 2 Gallamine (0.11 - 1.1 mM) produced a greater degree of antagnism towards CCh than towards ACh. With either agonist, the degree of antagonism produced by… CONTINUE READING


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