The inhibitory effect of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors

@article{Angerer2004TheIE,
  title={The inhibitory effect of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors},
  author={Erwin von Angerer and Jelica Prekajac and Martin R. Schneider and Martin R. Berger},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2004},
  volume={110},
  pages={216-220}
}
SummaryThe antineoplastic activity of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) was determined in several estrogen-dependent mammary tumor models. The growth of DMBA-induced rat mammary carcinomas was inhibited by doses ranging from 2 to 18 mg/kg. A dose of 6×12 mg/kg per week p.o. reduced the tumor area by 82% (control+192%). D 15413 was also active against MNU-induced rat mammary tumors and transplanted MXT tumors of the mouse. In vitro, the growth of… 
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Synthesis and Estrogen Receptor Affinity of 2,3‐Diarylindoles

2‐Phenylindoles with aromatic substituents at C‐3 and hydroxy functions at the aromatic rings were synthesized and tested for their binding affinity for the calf uterine estrogen receptor and the highest binding affinity was found with 3‐(4‐hydroxyphenyl)‐2‐phenylindole (3b).

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