The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells.

@article{Adachi2007TheIE,
  title={The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells.},
  author={Seiji Adachi and Tomokazu Nagao and Helgi I. Ing{\'o}lfsson and Frederick R Maxfield and Olaf S Andersen and Levy Kopelovich and I. Bernard Weinstein},
  journal={Cancer research},
  year={2007},
  volume={67 13},
  pages={6493-501}
}
(-)-Epigallocatechin gallate (EGCG), a major biologically active constituent of green tea, inhibits activation of the epidermal growth factor (EGF) receptor (EGFR) and downstream signaling pathways in several types of human cancer cells, but the precise mechanism is not known. Because several plasma membrane-associated receptor tyrosine kinases (RTK) including EGFR are localized in detergent-insoluble ordered membrane domains, so-called "lipid rafts," we examined whether the inhibitory effect… CONTINUE READING