The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding.

@article{Jennings2013TheIC,
  title={The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding.},
  author={Joshua H. Jennings and Giorgio Rizzi and Alice M Stamatakis and Randall L. Ung and Garret D. Stuber},
  journal={Science},
  year={2013},
  volume={341 6153},
  pages={1517-21}
}
The growing prevalence of overeating disorders is a key contributor to the worldwide obesity epidemic. Dysfunction of particular neural circuits may trigger deviations from adaptive feeding behaviors. The lateral hypothalamus (LH) is a crucial neural substrate for motivated behavior, including feeding, but the precise functional neurocircuitry that controls LH neuronal activity to engage feeding has not been defined. We observed that inhibitory synaptic inputs from the extended amygdala… CONTINUE READING
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