The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells.

@article{Trudel2006TheIA,
  title={The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells.},
  author={Suzanne Trudel and Alexander Stewart and Eran Rom and Ellen N Wei and Zhi Li and Sarit Kotzer and Irina Chumakov and Yossi Singer and Hong Chang and Sheng-ben Liang and Avner Yayon},
  journal={Blood},
  year={2006},
  volume={107 10},
  pages={4039-46}
}
The association of fibroblast growth factor receptor 3 (FGFR3) expression with t(4;14) multiple myeloma (MM) and the demonstration of the transforming potential of this receptor tyrosine kinase (RTK) make it a particularly attractive target for drug development. We report here a novel and highly specific anti-FGFR3-neutralizing antibody (PRO-001). PRO-001 binds to FGFR3 expressed on transformed cells and inhibits FGFR3 autophosphorylation and downstream signaling. The antibody inhibited the… CONTINUE READING
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