The inhibitory action of suramin on the P2-purinoceptor response in smooth muscle cells of guinea-pig taenia caeci.

  title={The inhibitory action of suramin on the P2-purinoceptor response in smooth muscle cells of guinea-pig taenia caeci.},
  author={A den Hertog and Adriaan Nelemans and Jeroen van den Akker},
  journal={European journal of pharmacology},
  volume={166 3},
Effects of ATP antagonists on purinoceptor-operated inward currents in rat phaeochromocytoma cells
Results suggest that suramin and RB2 reversibly block binding of ATP to receptors, whereas d-TC blocks ion permeability through the ATP-activated channel, suggesting that RB2 is a slowly acting antagonist.
Purinoceptors in neuromuscular transmission.
The P2‐purinoceptor antagonist suramin is a competitive antagonist at vasoactive intestinal peptide receptors in the rat gastric fundus
The results suggest that suramin acts as a competitive antagonist at VIP receptors in the rat gastric fundus, and the possible involvement of ATP in EFS‐induced NANC relaxations is investigated.
Effects of the P2‐purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5′‐diphosphate
Results provide evidence that the ADP receptor on human platelets is indeed similar to the P2‐purinoceptors responding to adenine nucleotides on smooth muscle and other tissues, and show that suramin cannot distinguish between the proposed subtypes of the P1‐purINOceptors.


Indications for P2-purinoceptor subtypes in guinea pig smooth muscle.
Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens
Results suggest that Suramin may provide a starting point for the development of specific antagonists for P2‐purinoceptors in mouse vas deferens.
Action of externally applied adenosine triphosphate on single smooth muscle cells dispersed from rabbit ear artery.
These results are consistent with ATP activating a conductance that is cation selective but allows both monovalent and divalent cations to pass across the membrane.
Studies on the stereoselectivity of the P2‐purinoceptor on the guinea‐pig vas deferens
These results show that unlike the P2‐purinoceptor mediating excitatory responses in the guinea‐pig bladder, the P1‐purinosome mediating contraction in the Guinea‐Pig vas deferens displays stereoselectivity.
Calcium and the action of adrenaline, adenosine triphosphate and carbachol on guinea‐pig taenia caeci
It is concluded that ATP and the α-agonist, after binding to their receptor sites, activate the same mechanism, which is mobilization of calcium from the same membrane compartment to open potassium channels, causingHyperpolarization of the muscle cell membrane depending on the availability of external calcium to replenish the calcium compartment localized in the membrane.