The inhibitory action of long-chain fatty acids on the DNA binding activity of p53

  title={The inhibitory action of long-chain fatty acids on the DNA binding activity of p53},
  author={H. Iijima and N. Kasai and H. Chiku and S. Murakami and F. Sugawara and K. Sakaguchi and H. Yoshida and Y. Mizushina},
  • H. Iijima, N. Kasai, +5 authors Y. Mizushina
  • Published 2006
  • Biology, Medicine
  • Lipids
  • The in vitro relationship between human p53 DNA binding domain (p53 DBD) and FA was investigated. We found that saturated and monounsaturated long-chain FA inhibited the double-stranded DNA (dsDNA) binding activity of p53 DBD. The strongest inhibitors of saturated and unsaturated FA were docosanoic acid (22∶0) and cis-12-heneicosenoic acid (21∶1n−9), respectively. n-Octadecane, trans-unsaturated FA, and FAME had no influence on the binding activity of p53 DBD, showing that the FA structures… CONTINUE READING
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