The inhibitory action of long-chain fatty acids on the DNA binding activity of p53

@article{Iijima2006TheIA,
  title={The inhibitory action of long-chain fatty acids on the DNA binding activity of p53},
  author={H. Iijima and N. Kasai and H. Chiku and S. Murakami and F. Sugawara and K. Sakaguchi and H. Yoshida and Y. Mizushina},
  journal={Lipids},
  year={2006},
  volume={41},
  pages={521-527}
}
  • H. Iijima, N. Kasai, +5 authors Y. Mizushina
  • Published 2006
  • Biology, Medicine
  • Lipids
  • The in vitro relationship between human p53 DNA binding domain (p53 DBD) and FA was investigated. We found that saturated and monounsaturated long-chain FA inhibited the double-stranded DNA (dsDNA) binding activity of p53 DBD. The strongest inhibitors of saturated and unsaturated FA were docosanoic acid (22∶0) and cis-12-heneicosenoic acid (21∶1n−9), respectively. n-Octadecane, trans-unsaturated FA, and FAME had no influence on the binding activity of p53 DBD, showing that the FA structures… CONTINUE READING
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    References

    SHOWING 1-10 OF 23 REFERENCES
    p53 and human cancer: the first ten thousand mutations.
    • 957
    Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
    • 2,306
    • Highly Influential
    A model for p53-induced apoptosis
    • 2,406
    Effects of gamma-linolenic acid and arachidonic acid on cell cycle progression and apoptosis induction in normal and transformed cells.
    • 42
    Spectroscopic studies of the structural domains of mammalian DNA beta-polymerase.
    • 51
    Participation of p53 protein in the cellular response to DNA damage.
    • 3,839
    • PDF