The inhibitory action of exo- and endocannabinoids on [³H]GABA release are mediated by both CB₁and CB₂receptors in the mouse hippocampus.

@article{And2012TheIA,
  title={The inhibitory action of exo- and endocannabinoids on [³H]GABA release are mediated by both CB₁and CB₂receptors in the mouse hippocampus.},
  author={R{\'o}me{\'o} D. And{\'o} and Judit B{\'i}r{\'o} and Cec{\'i}lia Cs{\"o}lle and Catherine A. Ledent and Be{\'a}ta Sperl{\'a}gh},
  journal={Neurochemistry international},
  year={2012},
  volume={60 2},
  pages={145-52}
}
Exogenous and endogenous cannabinoids play an important role in modulating the release of neurotransmitters in hippocampal excitatory and inhibitory networks, thus having profound effect on higher cognitive and emotional functions such as learning and memory. In this study we have studied the effect of cannabinoid agonists on the potassium depolarization-evoked [(3)H]GABA release from hippocampal synaptosomes in the wild-type (WT) and cannabinoid 1 receptor (CB(1)R)-null mutant mice. All tested… CONTINUE READING