The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury

@article{Wang2013TheIA,
  title={The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury},
  author={Xiaoyan Wang and Lining Zhang and Zengtao Wei and Xia Zhang and Qi Gao and Yanyan Ma and Xingli Liu and Yang Jiang and Xianglan Liu and Chun Guo},
  journal={Laboratory Investigation},
  year={2013},
  volume={93},
  pages={291-302}
}
Programmed cell death 4 (PDCD4) acts as a tumor suppressor gene, which suppresses tumor growth, infiltration and metastasis. Our previous studies demonstrated that PDCD4 had an important role in the development of ovarian cancer and glioma. Recent studies show that PDCD4 is also involved in various inflammatory diseases. However, its exact effect on inflammation remains unclear. In our current study, we explored the role of PDCD4 in acute liver injury induced by lipopolysaccharide (LPS) and D… CONTINUE READING

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The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death.

Proceedings of the National Academy of Sciences of the United States of America • 2011

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