The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein.

@article{Axton1994TheIO,
  title={The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein.},
  author={J. Myles Axton and Fay L Shamanski and Lauren M Young and D. B. Henderson and James B. Boyd and Terry L Orr-Weaver},
  journal={The EMBO journal},
  year={1994},
  volume={13 2},
  pages={462-70}
}
The plutonium (plu) gene product controls DNA replication early in Drosophila development. plu mutant females lay unfertilized eggs that have undergone extensive DNA synthesis. In fertilized embryos from plu mutant mothers, S-phase is uncoupled from mitosis. The gene is expressed only in ovaries and embryos, null alleles are strict maternal effect mutations, and the phenotype of inappropriate DNA replication is the consequence of loss-of-gene function. plu therefore negatively regulates S-phase… CONTINUE READING

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