The inhibition of the insulin receptor by the receptor protein PC-1 is not specific and results from the hydrolysis of ATP.

@article{Stefan1996TheIO,
  title={The inhibition of the insulin receptor by the receptor protein PC-1 is not specific and results from the hydrolysis of ATP.},
  author={Cristiana Stefan and Stefaan Wera and Willy Stalmans and Mathieu Bollen},
  journal={Diabetes},
  year={1996},
  volume={45 7},
  pages={980-3}
}
The membrane protein plasma cell differentiation antigen 1 (PC-1) has been purified as an inhibitor of insulin receptor tyrosine kinase activity and has been implicated in the pathogenesis of NIDDM. However, we show here that PC-1 is a general protein kinase inhibitor in vitro and that this inhibition results from the hydrolysis of ATP by the intrinsic nucleotide pyrophosphatase activity of PC-1. Thus, the inhibition diminished with increasing ATP concentrations, and it was nullified when the… CONTINUE READING