The inhibition of single N-methyl-D-aspartate-activated channels by zinc ions on cultured rat neurones.

@article{Legendre1990TheIO,
  title={The inhibition of single N-methyl-D-aspartate-activated channels by zinc ions on cultured rat neurones.},
  author={Pascal Legendre and Gary L Westbrook},
  journal={The Journal of physiology},
  year={1990},
  volume={429},
  pages={429-49}
}
1. Single channels activated by N-methyl-D-aspartate (NMDA) were studied in outside-out patches of cultured hippocampal neurones in the presence of glycine and absence of magnesium. The effects of the transition metal ions zinc and cadmium on NMDA channels were tested by placing the membrane patch at the mouth of one of an array of large barrelled flow pipes. 2. Amplitude histograms revealed several conductance levels between 5 and 45 pS with the majority of NMDA-activated openings greater than… CONTINUE READING

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