The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses.

  title={The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses.},
  author={Jeffrey O'Sullivan and Michael I O'Sullivan and Keith F. Tipton and Mercedes Unzeta and Mar{\'i}a del Mar Hern{\'a}ndez and Gavin P. Davey},
  journal={Biochimica et biophysica acta},
  volume={1647 1-2},
Semicarbazide-sensitive amine oxidase (EC; amine:oxygen oxidoreductase (deaminating) (copper-containing); SSAO) is a multifunctional protein. It acts under inflammatory conditions as a vascular-adhesion protein (VAP-1), mediating the adhesion of lymphocytes to vascular endothelial cells. The relationships, if any, between this adhesion function and the enzymatic functions (amine-substrate specificity and catalysis) of SSAO have not yet been defined. Since cell surface amino sugars and… CONTINUE READING