The inhibition of renin secretion in the isolated rat kidney by clonidine hydrochloride (Catapres).


1. The effect of clonidine HCl on basal and isoprenaline-stimulated renin secretion was examined in the isolated rat kidney. 2. Intrarenal infusion of clonidine at a dose level which did not increase renal perfusion pressure (1.9 nmol min-1 g-1), significantly lowered basal renin secretion without altering the stimulatory response to isoprenaline. 3… (More)


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