The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.

@article{Wiemer1995TheIO,
  title={The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.},
  author={E A Wiemer and Paul A. M. Michels and Fred R. Opperdoes},
  journal={The Biochemical journal},
  year={1995},
  volume={312 ( Pt 2)},
  pages={479-84}
}
The pyruvate produced by glycolysis in the bloodstream form of the trypanosome is excreted into the host bloodstream by a facilitated diffusion carrier. The sensitivity of pyruvate transport for alpha-cyano-4-hydroxycinnamate and the compound UK5099 [alpha-cyano-beta-(1-phenylindol-3-yl)acrylate], which are known to be selective inhibitors of pyruvate (monocarboxylate) transporters present in mitochondria and the plasma membrane of eukaryotic cells, was examined. The trypanosomal pyruvate… CONTINUE READING

Similar Papers

Loading similar papers…