The inhibition of premature labor with indomethacin.

  title={The inhibition of premature labor with indomethacin.},
  author={Jennifer R Niebyl and David Blake and Robert D White and Karen M. Kumor and Norman H. Dubin and J. Courtland Robinson and Patricia G Egner},
  journal={American journal of obstetrics and gynecology},
  volume={136 8},
We administered indomethacin orally for the treatment of premature labor in a prospective, randomized, double-blind fashion, and all infants were followed up. Indomethacin was significantly more effective than placebo in inhibition of premature labor during a 24-hour course of therapy, with treatment failure during therapy occurring in only one of 15 indomethacin-treated patients compared to nine of 15 placebo-treated patients (p less than 0.01). Mean plasma concentrations of indomethacin were… CONTINUE READING


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