The inhibition of postinfarct ventricle remodeling without polycythaemia following local sustained intramyocardial delivery of erythropoietin within a supramolecular hydrogel.

@article{Wang2009TheIO,
  title={The inhibition of postinfarct ventricle remodeling without polycythaemia following local sustained intramyocardial delivery of erythropoietin within a supramolecular hydrogel.},
  author={Tao Wang and Xuejun Jiang and Tao Lin and Shan Ren and Xiao-yan Li and Xianzheng Zhang and Qi-Zhu Tang},
  journal={Biomaterials},
  year={2009},
  volume={30 25},
  pages={4161-7}
}
Erythropoietin (EPO) can protect myocardium from ischemic injury, but it also plays an important role in promoting polycythaemia, the potential for thrombo-embolic complications. Local sustained delivery of bioactive agents directly to impaired tissues using biomaterials is an approach to limit systemic toxicity and improve the efficacy of therapies. The present study was performed to investigate whether local intramyocardial injection of EPO with hydrogel could enhance cardioprotective effect… CONTINUE READING

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