The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.

@article{Marecki2002TheIO,
  title={The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.},
  author={John C. Marecki and J M Mccord},
  journal={Archives of biochemistry and biophysics},
  year={2002},
  volume={402 2},
  pages={227-34}
}
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which is activated in response to genotoxic insults by binding damaged DNA and attaching polymers of ADP-ribose to nuclear proteins at the expense of its substrate NAD+. In persons affected with ataxia telangiectasia (A-T), associated mutations in the ataxia telangiectasia mutated gene render cells unable to cope with the genotoxic stresses from ionizing radiation and oxidative damage, thus resulting in a higher concentration of unrepaired… CONTINUE READING

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