The inhibition of nucleic acid synthesis by mycophenolic acid.

  title={The inhibition of nucleic acid synthesis by mycophenolic acid.},
  author={Trevor J Franklin and James M Cook},
  journal={The Biochemical journal},
  volume={113 3},
1. Mycophenolic acid, an antibiotic of some antiquity that more recently has been found to have marked activity against a range of tumours in mice and rats, strongly inhibits DNA synthesis in the L strain of fibroblasts in vitro. 2. The extent of the inhibition of DNA synthesis is markedly increased by preincubation of the cells with mycophenolic acid before the addition of [(14)C]thymidine. 3. The inhibition of DNA synthesis by mycophenolic acid in L cells in vitro is reversed by guanine in a… CONTINUE READING


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