The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.

@article{Matsushima2008TheIO,
  title={The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.},
  author={Soichiro Matsushima and Kazuya Maeda and Katsuhisa Inoue and Kin-ya Ohta and Hiroaki Yuasa and Tsunenori Kondo and Hideki Nakayama and Shigeru Horita and Hiroyuki Kusuhara and Yuichi Sugiyama},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={37 3},
  pages={
          555-9
        }
}
Cimetidine is known to cause drug-drug interactions (DDIs) with organic cations in the kidney, and a previous clinical study showed that coadministration of cimetidine or probenecid with fexofenadine (FEX) decreased its renal clearance. FEX was taken up into human kidney by human organic anion transporter (hOAT) 3 (SLC22A8), but the mechanism of its luminal efflux has not been clarified. The present study examined the molecular mechanism of these DDIs. Saturable uptake of FEX was observed in… CONTINUE READING

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