The inhibition of histamine formation in vivo

@article{Mole1973TheIO,
  title={The inhibition of histamine formation in vivo},
  author={K. Mole and D. M. Shepherd},
  journal={Journal of Pharmacy and Pharmacology},
  year={1973},
  volume={25}
}
Histamine formation was measured by the [14C]histamine content of the stomach following injection of [14C]histidine into rats. Carbonyl reagents (e.g. oxyamines) which inactivate pyridoxal phosphate, the co‐enzyme of histidine decarboxylase, were the most effective inhibitors of histamine formation in vivo. Although the oximes prepared from imidazol‐4(5)‐ylmethoxyamine and pyridoxal or pyridoxal phosphate cannot inactivate the co‐enzyme, they proved sufficiently potent to merit further study as… Expand

References

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Observations on the inhibition of histamine formation
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