The inhibition of autoreactive T cell functions by a peptide based on the CDR1 of an anti-DNA autoantibody is via TGF-beta-mediated suppression of LFA-1 and CD44 expression and function.

@article{Sela2005TheIO,
  title={The inhibition of autoreactive T cell functions by a peptide based on the CDR1 of an anti-DNA autoantibody is via TGF-beta-mediated suppression of LFA-1 and CD44 expression and function.},
  author={Uri Sela and Nora Mauermann and Rami Hershkoviz and Heidy Zinger and Molly Dayan and Liora Cahalon and Jian Ping Liu and Edna Mozes and Ofer Lider},
  journal={Journal of immunology},
  year={2005},
  volume={175 11},
  pages={
          7255-63
        }
}
Systemic lupus erythematosus (SLE), which is characterized by the increased production of autoantibodies and defective T cell responses, can be induced in mice by immunization with a human anti-DNA mAb that expresses a major Id, designated 16/6Id. A peptide based on the sequence of the CDR1 of the 16/6Id (human CDR1 (hCDR1)) ameliorated the clinical manifestations of SLE and down-regulated, ex vivo, the 16/6Id-induced T cell proliferation. In this study, we examined the mechanism responsible… CONTINUE READING
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