The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.

Abstract

FcγRIIB-deficient mice generated in 129 background (FcγRIIB(129)(-/-)) if back-crossed into C57BL/6 background exhibit a hyperactive phenotype and develop lethal lupus. Both in mice and humans, the Fcγr2b gene is located within a genomic interval on chromosome 1 associated with lupus susceptibility. In mice, the 129-derived haplotype of this interval, named… (More)
DOI: 10.4049/jimmunol.1101194

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