The inherited leukodystrophies: A clinical overview

  title={The inherited leukodystrophies: A clinical overview},
  author={J. P. Aicardi},
  journal={Journal of Inherited Metabolic Disease},
The leukodystrophies are degenerative diseases that involve primarily the white matter of the brain. The most common leukodystrophies result from known disturbances in the synthesis or catabolism of myelin such as a block in the catabolism of sulphatides and of galactocerebrosides, respectively, in metachromatic leukodystrophy and in Krabbe disease, or from synthesis of an abnormal proteolipid protein in Pelizaeus-Merzbacher disease. The cause of white matter involvement in other… CONTINUE READING


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