The inheritance of Alzheimer's disease: a new interpretation.

  title={The inheritance of Alzheimer's disease: a new interpretation.},
  author={Naomi Fitch and Ruediger Becker and Andrew Heller},
  journal={Annals of neurology},
  volume={23 1},
Ninety-one families of Alzheimer patients were studied to determine the proportion of familial cases, to obtain pedigrees for the analysis of the mode of inheritance, and to look for clinical differences between the familial and the nonfamilial cases. The diagnosis was confirmed by autopsy in 26 cases. Thirty-nine cases (43%) were familial, which is defined as more than one case in the family. Our interpretation of the pedigree data is that Alzheimer's disease is etiologically heterogeneous: it… CONTINUE READING

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