The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.

@article{Terzian2008TheII,
  title={The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.},
  author={Tamara Terzian and Young-Ah Suh and Tomoo Iwakuma and Sean M. Post and Manja Neumann and Gene Anthony Lang and Carolyn S. Van Pelt and Guillermina Lozano},
  journal={Genes & development},
  year={2008},
  volume={22 10},
  pages={
          1337-44
        }
}
The p53 tumor suppressor is often disrupted in human cancers by the acquisition of missense mutations. We generated mice with a missense mutation at codon 172 that mimics the p53R175H hot spot mutation in human cancer. p53 homozygous mutant mice have unstable mutant p53 in normal cells and stabilize mutant p53 in some but not all tumors. To investigate the significance of these data, we examined the regulation of mutant p53 stability by Mdm2, an E3 ubiquitin ligase that targets p53 for… CONTINUE READING
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