The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β.

@article{Wu2012TheIA,
  title={The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β.},
  author={Xu Wu and Yan Lu and Yuanlin Dong and Guohua Zhang and Yiying Zhang and Zhipeng Xu and Deborah J. Culley and Gregory Crosby and Edward R. Marcantonio and Rudolph E. Tanzi and Zhongcong Xie},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 7},
  pages={1364-78}
}
Anesthetics have been reported to promote Alzheimer's disease (AD) neuropathogenesis by inducing β-amyloid protein accumulation and apoptosis. Neuroinflammation is associated with the emergence of AD. We therefore set out to determine the effects of the common anesthetic isoflurane on the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β, the proinflammatory cytokines, in vitro and in vivo, employing Western blot, immunohistochemistry, enzyme-linked immunosorbent assay… CONTINUE READING

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