The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

  title={The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype},
  author={I. R. Klein-Wieringa and Margreet Kloppenburg and Yvonne M. Bastiaansen‐Jenniskens and Erlangga Yusuf and J. C. Kwekkeboom and Hanane el-Bannoudi and Rob G.H.H. Nelissen and A M Zuurmond and Vedrana Stojanovic-Susulic and Gjvm van Osch and Rem Toes and Andreea Ioan-Facsinay},
  journal={Annals of the Rheumatic Diseases},
  pages={851 - 857}
Objectives Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects. The infrapatellar fat pad (IFP) is an intra-articular organ in the vicinity of the synovium and cartilage. It is hypothesised that IFP-derived soluble factors could contribute to pathological processes in the knee joint. A study was therefore undertaken to compare the release of inflammatory mediators in the… 

Infrapatellar fat pad of patients with end-stage osteoarthritis inhibits catabolic mediators in cartilage

Whether the infrapatellar fat pad (IPFP) closely located to cartilage in the knee joint can affect cartilage metabolism is examined and medium conditioned by end-stage OA IPFP inhibited catabolic processes in cartilage.

Inflammation of the infrapatellar fat pad.

Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study

OA IFPs and synovial membranes are more inflamed, vascularized and fibrous compared with those of control patients (without OA).

Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

BMI-related features usually observed in SCAT and visceral adipose tissue could not be detected in the IFP of OA patients, a fat depot implicated in OA pathogenesis.

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Source and hub of inflammation: The infrapatellar fat pad and its interactions with articular tissues during knee osteoarthritis

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Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals

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Modulation of Gene Expression in Infrapatellar Fat Pad–Derived Mesenchymal Stem Cells in Osteoarthritis

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The results indicate that the IFP cytokine profile typically found in OA patients could play a role in paracrine inflammation via the local production of IL-6/sIL-6R and that such a profile might contribute to damage in adjacent cartilage.

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These findings identify proinflammatory CD11c+ ATMs as markers of insulin resistance in human obesity and indicates they metabolize lipid and may initiate adaptive immune responses.

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