The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

@article{KleinWieringa2011TheIF,
  title={The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype},
  author={I. R. Klein-Wieringa and Margreet Kloppenburg and Yvonne M. Bastiaansen‐Jenniskens and Erlangga Yusuf and J. C. Kwekkeboom and Hanane el-Bannoudi and Rob G.H.H. Nelissen and A M Zuurmond and Vedrana Stojanovic-Susulic and Gjvm van Osch and Rem Toes and Andreea Ioan-Facsinay},
  journal={Annals of the Rheumatic Diseases},
  year={2011},
  volume={70},
  pages={851 - 857}
}
Objectives Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects. The infrapatellar fat pad (IFP) is an intra-articular organ in the vicinity of the synovium and cartilage. It is hypothesised that IFP-derived soluble factors could contribute to pathological processes in the knee joint. A study was therefore undertaken to compare the release of inflammatory mediators in the… 

Infrapatellar fat pad of patients with end-stage osteoarthritis inhibits catabolic mediators in cartilage

TLDR
Whether the infrapatellar fat pad (IPFP) closely located to cartilage in the knee joint can affect cartilage metabolism is examined and medium conditioned by end-stage OA IPFP inhibited catabolic processes in cartilage.

Inflammation of the infrapatellar fat pad.

Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study

TLDR
OA IFPs and synovial membranes are more inflamed, vascularized and fibrous compared with those of control patients (without OA).

Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

TLDR
BMI-related features usually observed in SCAT and visceral adipose tissue could not be detected in the IFP of OA patients, a fat depot implicated in OA pathogenesis.

Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad

TLDR
The data suggest that the immune cell composition of the synovium and the IFP is similar, and includes activated cells that could contribute to inflammation through secretion of proinflammatory cytokines.

Inflammatory features of infrapatellar fat pad in rheumatoid arthritis versus osteoarthritis reveal mostly qualitative differences

TLDR
The aim was to get a first insight into the possible contribution of IFP to the inflammatory processes in the RA joint, and to compare leftover IFP and synovium from patients with RA and patients with primary knee OA.

Source and hub of inflammation: The infrapatellar fat pad and its interactions with articular tissues during knee osteoarthritis

TLDR
Understanding the complex interplay between the infrapatellar fat pad and its neighboring articular tissues may help to better understand and treat the multifactorial pathogenesis of osteoarthritis.

Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals

TLDR
Experimental evidences confirm the critical role of adipokines with an emphasis on old members, such as leptin and visfatin, but also on new members such as chemerin, in OA and indicate that these factors exert pro-inflammatory and pro-catabolic actions at cartilage level.

Infrapatellar fat pad aggravates degeneration of acute traumatized cartilage: a possible role for interleukin-6.

Modulation of Gene Expression in Infrapatellar Fat Pad–Derived Mesenchymal Stem Cells in Osteoarthritis

TLDR
OA of the knee also affects the mesenchymal stem cells of Hoffafat, suggesting that Hoffa fat is a new actor in the OA degenerative process that can contribute to the origin, onset, and progression of the disease.
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References

SHOWING 1-10 OF 33 REFERENCES

The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor.

TLDR
The results indicate that the IFP cytokine profile typically found in OA patients could play a role in paracrine inflammation via the local production of IL-6/sIL-6R and that such a profile might contribute to damage in adjacent cartilage.

Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids

TLDR
The production of bFGF, VEGF, TNFα, and IL6 in the infrapatellar fat pad was demonstrated, and the results suggest that they may also originate from this fat pad.

Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity.

TLDR
Preerential macrophage infiltration into OM fat is a general phenomenon exaggerated by central obesity, potentially linking central adiposity with increased risk of diabetes and coronary heart disease.

Obesity is associated with macrophage accumulation in adipose tissue.

TLDR
Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

TLDR
ATMs may be active players in the process of AT development through the extension of the capillary network and in the genesis of obesity-associated cardiovascular pathologies.

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

TLDR
These data suggest involvement of NK cells and IFN-γ in regulating ATM phenotype and function in human obesity and a potential mechanism for the adverse physiologic effects of VAT.

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

TLDR
These findings identify proinflammatory CD11c+ ATMs as markers of insulin resistance in human obesity and indicates they metabolize lipid and may initiate adaptive immune responses.

The association of obesity with osteoarthritis of the hand and knee in women: a twin study.

TLDR
Obesity is an important risk factor for development of OA at the tibiofemoral and patellofemoral joints of the knee and CMC joints ofThe hands, with significant increases of 9-13% in risk of Oa per kg increase in body weight.