The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

  title={The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.},
  author={A. Portela and P. Digard},
  journal={The Journal of general virology},
  volume={83 Pt 4},
  • A. Portela, P. Digard
  • Published 2002
  • Biology, Medicine
  • The Journal of general virology
  • All viruses with negative-sense RNA genomes encode a single-strand RNA-binding nucleoprotein (NP). The primary function of NP is to encapsidate the virus genome for the purposes of RNA transcription, replication and packaging. The purpose of this review is to illustrate using the influenza virus NP as a well-studied example that the molecule is much more than a structural RNA-binding protein, but also functions as a key adapter molecule between virus and host cell processes. It does so through… CONTINUE READING
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