The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction.

@article{Dauber2004TheIB,
  title={The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction.},
  author={Bianca Dauber and Gudrun Heins and Thorsten Wolff},
  journal={Journal of virology},
  year={2004},
  volume={78 4},
  pages={1865-72}
}
We analyzed the functions of the influenza B virus nonstructural NS1-B protein, both by utilizing a constructed mutant virus (Delta NS1-B) lacking the NS1 gene and by testing the activities of the protein when expressed in cells. The mutant virus replicated to intermediate levels in 6-day-old embryonated chicken eggs that contain an immature interferon (IFN) system, whereas older eggs did not support viral propagation to a significant extent. The Delta NS1-B virus was a substantially stronger… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Development of high-yield influenza B virus vaccine viruses.

Proceedings of the National Academy of Sciences of the United States of America • 2016

References

Publications referenced by this paper.
Showing 1-10 of 80 references

Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: outcome with influenza A virus is unique.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 6 Excerpts
Highly Influenced

FUNCTIONS OF INFLUENZA B VIRUS NS1 PROTEIN 1871 on A ril 22

Y. T. Juang, W. Lowther, +4 authors M P.
Proc. Natl. Acad. Sci. USA • 2004
View 1 Excerpt

Similar Papers

Loading similar papers…