The influences of propofol and dexmedetomidine on circadian gene expression in rat brain.

@article{Yoshida2009TheIO,
  title={The influences of propofol and dexmedetomidine on circadian gene expression in rat brain.},
  author={Yuko Z. Yoshida and Keiko Nakazato and Ken Takemori and Katsuya Kobayashi and Atsuhiro Sakamoto},
  journal={Brain research bulletin},
  year={2009},
  volume={79 6},
  pages={441-4}
}
INTRODUCTION There are circadian genes whose expressions were affected by sevoflurane. We hypothesized that propofol and dexmedetomidine also have influences on the expressions of circadian genes. MATERIALS AND METHODS Seven-week-old rats were cannulated and propofol (600 microg/kg/min, 1 ml/h, n=6: group P6H), dexmedetomidine (1 microg/kg/min, 1 ml/h, n=6: group D6H), 10% lipid (1 ml/h, n=6: group L) and normal saline (1 ml/h, n=6: group N) were infused intravenously for 6h; rats were… CONTINUE READING