The influence on the immunomodulatory effects of dying and dead cells of Annexin V.

@article{Munoz2007TheIO,
  title={The influence on the immunomodulatory effects of dying and dead cells of Annexin V.},
  author={Luis Enrique Munoz and Sandra Franz and Friederike Pausch and Barbara G F{\"u}rnrohr and A. Mohamed Ismail Sheriff and Birgit Vogt and Peter M Kern and Wolfgang Baum and Christian Stach and Dorothee von Laer and Bent Brachvogel and Ernst Poschl and Martin Herrmann and Udo S Gaipl},
  journal={Journal of leukocyte biology},
  year={2007},
  volume={81 1},
  pages={
          6-14
        }
}
Apoptotic and necrotic cells expose phosphatidylserine (PS). This membrane modification ensures a swift recognition and uptake by phagocytes of the dying and dead cells. Annexin V (AxV) preferentially binds to anionic phospholipids and thereby, modulates the clearance process. First, we analyzed the influence of AxV on the immunogenicity of apoptotic cells. The addition to apoptotic cells of AxV prior to their injection into mice increased their immunogenicity significantly. Next, we studied… CONTINUE READING
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