The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon

@article{Oberle1987TheIO,
  title={The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon},
  author={Rebecca L. Oberle and Gordon L Amidon},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1987},
  volume={15},
  pages={529-544}
}
A physiological flow model is presented to account for plasma level double peaks based on cyclical gastric emptying and intestinal motility in the fasted state. Central to the model is the assumption that gastric emptying and intestinal transit rates will vary directly with the strength of the contractile activity characteristic of the fasted state motility cycle. Simulated curves clearly indicate that variable gastric emptying rates can result in variable absorption rates from the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

PDZK1 regulates breast cancer resistance protein in small intestine.

Drug metabolism and disposition: the biological fate of chemicals • 2011
View 4 Excerpts
Highly Influenced

Cimetidine absorption and elimination in rat small intestine.

Drug metabolism and disposition: the biological fate of chemicals • 2000
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 41 references

A radiotelemetric method for evaluation of enteric coating performance : comparison of enteric coated and plain aspirin tablets

C. Y. Lui, R. Oberle, D. Fleisher, G. L. Amidon
J . Pharm . Sci . • 1986

A radiotelemetric method for evaluation of enteric coating performance: comparison of enteric coated and plain aspirin

C. Y. Lui, R. Oberle, D. Fleisher, G. L. Amidon
tablets. J. Pharm. Sci • 1986

Gastric emptying of liquids in fasted dog. (abstract

P. K. Gupta, A. Rubinstein, J. R. Robinson
Pharm. Res • 1986

Clinical Gastrointestinal Physiology, W

D. N. Granger, J. A. Barrowman, P. R. Kvietys
B. Saunders, Philadelphia, • 1985

Relationship between different phases of MMC and transit time: A reappraisal. Gastroenterology

S. K. Sarna, H. V. Ammon, L. G. Walter, R. P. Ryan
1985

The pharmacokinetics of sobrerol in normal human volunteers

U. Shukla
Ph.D. Dissertation, University of Michigan, • 1985

Similar Papers

Loading similar papers…