The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea—an in vitro study

@article{Ouschan2011TheIO,
  title={The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea—an in vitro study},
  author={C. Ouschan and M. Lepschy and F. Zeugswetter and E. Moestl},
  journal={Veterinary Research Communications},
  year={2011},
  volume={36},
  pages={35-40}
}
  • C. Ouschan, M. Lepschy, +1 author E. Moestl
  • Published 2011
  • Chemistry, Medicine
  • Veterinary Research Communications
  • Trilostane is widely used to treat hyperadrenocorticism in dogs. Trilostane competitively inhibits the enzyme 3-beta hydroxysteroid dehydrogenase (3β-HSD), which converts pregnenolone (P5) to progesterone (P4) and dehydroepiandrosterone (DHEA) to androstendione (A4). Although trilostane is frequently used in dogs, the molecular mechanism underlying its effect on canine steroid hormone biosynthesis is still an enigma. Multiple enzymes of 3β–HSD have been found in humans, rats and mice and their… CONTINUE READING
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