The influence of transforming growth factor‐α, cyclooxygenase‐2, matrix metalloproteinase (MMP)‐7, MMP‐9 and CXCR4 proteins involved in epithelial–mesenchymal transition on overall survival of patients with gastric cancer

  title={The influence of transforming growth factor‐$\alpha$, cyclooxygenase‐2, matrix metalloproteinase (MMP)‐7, MMP‐9 and CXCR4 proteins involved in epithelial–mesenchymal transition on overall survival of patients with gastric cancer},
  author={Marcello Ferretti Fanelli and Ludmilla T. D. Chinen and Maria D. Begnami and Wilson Luis Costa and Jos{\'e} Humberto T Fregnami and Fernando Augusto Soares and Andr{\'e} Luis Montagnini},
Fanelli M F, Chinen L T D, Begnami M D, Costa W L Jr, Fregnami J H T, Soares F A & Montagnini A L 
(2012) Histopathology 61, 153–161 
Matrix metalloproteinase‐7 and matrix metalloproteinase‐25 in oral tongue squamous cell carcinoma
MMPs are examined in oral tongue SCC as matrix metalloproteinases associated with invasion, metastasis, and poor survival in many cancers, and MMP‐7 and M MP‐25 are examined.
Coexpression of Matrix Metalloproteinase-7 and Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Biomarker in Gastric Cancer
Coexpression of MMP-7 and its inhibitor TIMP-1 in gastric tumour tissues is a potential prognostic marker for GC and greater knowledge of protein expression will lead to new paradigms and possible improvements in therapeutics.
The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition
How COX-2 overexpression, within the context of the TME, orchestrates the EMT process and promotes initial metastatic-related events is summarized.
The Role of Matrix Metalloproteinase-2 Expression in Gastric Cancer Susceptibility: A Systematic Review
MMP2 over-expression can play a critical role in tumor metastasis, tumor size, invasion, and lymph node invasion in GC and may play a crucial role in degrading extracellular matrix as well as stimulate angiogenesis.
COX-2 regulates Snail expression in gastric cancer via the Notch1 signaling pathway.
COX‑2 inversely regulated notch1 in GC and partially depended on the Notch1 signalling pathway in altering the expression of Snail, which was found to be related to the depth of invasion and TNM staging.
Tepotinib Inhibits the Epithelial–Mesenchymal Transition and Tumor Growth of Gastric Cancers by Increasing GSK3β, E-Cadherin, and Mucin 5AC and 6 Levels
It is suggested that tepotinib suppresses tumor growth and migration by negatively regulating c-MET-induced EMT, providing new insights into the mechanism by which MUC5AC and MUC6 contribute to GC progression.
The essential roles of CCR7 in epithelial-to-mesenchymal transition induced by hypoxia in epithelial ovarian carcinomas
CCR7 can constitutively express in epithelial ovarian carcinomas and be induced rapidly in response to hypoxia, which indeed participates in EMT development and prompts the cell migration and invasion.
New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
COX-2 expression as a predictor of survival in various cancer types, including breast, is reviewed and the COx-2 mediated mechanisms contributing to the growth of cancers are outlined.
Integrin αvβ6 and matrix metalloproteinase 9 correlate with survival in gastric cancer.
The combinational pattern of αvβ6 and MMP-9 can serve as a more effective prognostic index for gastric cancer patients and is confirmed by a correlation analysis.


Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma
MMPs are examined in human gastric adenocarcinoma tissues and the correlation between their expression and clinicopathological variables is found to be positive.
Prognostic importance of epithelial–mesenchymal transition‐related protein expression in gastric carcinoma
The aim was to evaluate the expression of EMT‐related proteins in gastric carcinoma (GC) by analyzing the switching of polarized epithelial cells to a migratory fibroblastoid phenotype.
Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis.
Evidence is provided that COX-2 contribute to gastric cancer development by promoting MMP-9 expression and angiogenesis, and this expression is related to tumor invasion and lymph node metastasis in the gastric carcinoma.
Molecular-pathological prognostic factors of gastric cancer: a review
Comprehensive gene expression analyses are useful to search for novel genes related to invasion and metastasis and potential prognostic factors and combination of these examinations can not only foretell a patient’s prognosis but can also give information directly connected with personalized cancer medicine and prevention.
Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival.
  • D. Lazăr, S. Tăban, C. Vernic
  • Medicine
    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • 2008
The results obtained are suggestive for the predominant expression of COX-2 in the carcinomas of intestinal type and its precursory lesions and show a tight correlation between the immunohistochemical expressions of COx-2 and VEGF in gastric carcinomas.
Relation of neuroendocrine cells to transforming growth factor-alpha and epidermal growth factor receptor expression in gastric adenocarcinomas: Prognostic implications
The results of this study suggest that the presence of NE cells may have an effect on the expression of TGF-a and EGFR in GCa, and the autocrine mechanism between T GF-α and EG FR plays an important role in the prognosis of gastric carcinoma.
Matrix metalloproteinases: biologic activity and clinical implications.
The preclinical and clinical evolution of the synthetic MMP inhibitors (MMPIs) is examined, with the discussion encompassing important methodologic issues associated with determining clinical efficacy of MMPIs and other novel therapeutic agents.
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.
A model for the cellular adaptation to the hypoxic tumour microenvironment that encompasses the interplay between COX-2, hypoxia-inducible factor 1 and dynamic switches in beta-catenin function that fine-tune signalling networks to meet the ever-changing demands of a tumour is proposed.
Overexpression of cyclooxygenase‐2 protein is less frequent in gastric cancers with microsatellite instability
The results suggest that overexpression of COX‐2 may play an important role in tumor progression of gastric cancer and also support the notion that gastric cancers with and without MSI represent distinctive pathways of carcinogenesis.
Clinical significance of matrix metalloproteinase-7 expression in esophageal carcinoma.
The findings indicated that MMP-7 might be a novel prognostic factor for patients with esophageal carcinoma.