The influence of tick behavior, biotope and host specificity on concerted evolution of the platelet aggregation inhibitor savignygrin, from the soft tick Ornithodoros savignyi.

@article{Mans2003TheIO,
  title={The influence of tick behavior, biotope and host specificity on concerted evolution of the platelet aggregation inhibitor savignygrin, from the soft tick Ornithodoros savignyi.},
  author={B. Mans and A. Louw and A. Neitz},
  journal={Insect biochemistry and molecular biology},
  year={2003},
  volume={33 6},
  pages={
          623-9
        }
}
Ticks are obligate blood-feeding parasites that secrete anti-hemostatic components during feeding to enable control of the hemostatic system of the host. Complex interactions at the tick-host interface are an indication of the important role that the host played during tick evolution. The question is to what extent interaction with the host and the environment influences tick evolution. Previously, two isoforms (97% sequence identity) of savignygrin, an alphaIIbbeta3 antagonist, have been… Expand
Adaptation of ticks to a blood-feeding environment: evolution from a functional perspective.
  • B. Mans, A. Neitz
  • Biology, Medicine
  • Insect biochemistry and molecular biology
  • 2004
TLDR
It is concluded that the main tick families adapted independently to a blood-feeding environment and this has several implications for future tick research in terms of tick genome projects and vaccine development. Expand
Gene Duplication and Protein Evolution in Tick-Host Interactions
TLDR
This review considers the possibilities of ancient genome duplication, lineage specific expansion events, and the role that positive selection played in the evolution of tick protein function and contrasts current views in tick biology regarding adaptive evolution with the more general view that neutral evolution may account for the majority of biological innovations observed in ticks. Expand
The sand tampan, Ornithodoros savignyi , as a model for tick-host interactions : review article
TLDR
The study of anti-haemostatic components secreted by the tampan indicates a close evolutionary relationship between different anti-HAEMostatic mechanisms, which has several implications for general tick biology, the most important being that the main tick families adapted independently to a blood-feeding lifestyle and that the different forms of tick toxicoses have distinct origins. Expand
Characterization of anti-hemostatic factors in the argasid, Argas monolakensis: implications for the evolution of blood-feeding in the soft tick family.
TLDR
The Argas derived anti-hemostatic factors bind to mammalian targets with affinities similar to that observed for their orthologs in the Ornithodoros genus, implying that the anti- hemostatics factors evolved in the ancestral soft tick lineage and has been maintained in soft tick species from two distinct genera with different host preferences. Expand
Chemical Equilibrium at the Tick–Host Feeding Interface:A Critical Examination of Biological Relevance in Hematophagous Behavior
  • B. Mans
  • Chemistry, Medicine
  • Front. Physiol.
  • 2019
TLDR
Cognisance of the limitations that equilibrium binding place on deductions of functional relevance should serve as an important incentive to determine both the concentration and affinity of tick proteins proposed to be functional at the feeding site. Expand
Identification and Characterization of Sialidase-Like Activity in the Developmental Stages of Amblyomma variegatum
TLDR
The finding established the presence of type II sialidase-like activity in the three stages (larva, nymph, and adult) of the fed and unfed tick, and contribute to the preliminary characterization of the A. variegatum salivary proteome, and may pave way to the development of new acaricides. Expand
Amblyomma americanum tick saliva serine protease inhibitor 6 is a cross‐class inhibitor of serine proteases and papain‐like cysteine proteases that delays plasma clotting and inhibits platelet aggregation
TLDR
It is demonstrated that AamS6 is a cross‐class inhibitor of both serine‐ and papain‐like cysteine proteases that has apparent antihaemostatic functions and is most likely not involved with the tick's evasion of the host's complement defense mechanism. Expand
Analysis of the reasons for differences in topical specificity among various species of tick (Acari, Ixodidae) infesting European bison
TLDR
Ticks do, however, exhibit distinct topical specificity during feeding, and in the case of D. reticulatus a significant factor is the correlation between the length of the gnathosoma and the skin thickness of the host, which determines the availability of the circulatory vessels. Expand
An insight into the salivary transcriptome and proteome of the soft tick and vector of epizootic bovine abortion, Ornithodoros coriaceus.
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The results indicate that each genus of hematophagous arthropods studied to date evolved unique protein families that assist blood feeding, thus characterizing potentially new pharmacologically active components or antimicrobial agents. Expand
Ancestral reconstruction of tick lineages.
TLDR
An attempt is made to delineate the current knowledge with regard to the ancestral reconstruction of the tick (Ixodida) lineage, indicating modification with descent, as expected for Darwinian evolutionary theory. Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Evolution of hematophagy in ticks: common origins for blood coagulation and platelet aggregation inhibitors from soft ticks of the genus Ornithodoros.
TLDR
Comparison with hemostatic inhibitors of hard ticks suggests that the two main tick families have independently evolved novel antihemostatic mechanisms, and independent evolution of these mechanisms in ticks points to a rapid divergence between tick families that could be dated between 120 and 92 MYA, which suggests this event might have been a driving force in the evolution of hematophagy in ticks. Expand
Argasid and nuttalliellid ticks as parasites and vectors.
TLDR
This chapter focuses on ticks and tick-borne diseases and reviews tick structures and physiology and discusses the tick cuticle. Expand
Savignygrin, a Platelet Aggregation Inhibitor from the Soft TickOrnithodoros savignyi, Presents the RGD Integrin Recognition Motif on the Kunitz-BPTI Fold*
TLDR
This is the first report of a platelet aggregation inhibitor that presents the RGD motif using the Kunitz-BPTI protein fold, and indicates the specificity of savignygrin toward αIIbβ3. Expand
Evolution of ticks.
TLDR
An analysis of tick-host and -habitat associations and biogeographical patterns, in the context of the newly derived phylogenies, suggests that much of the existing host-association patterns may be explained as artifacts of biogeography and ecological specificity. Expand
Disagregin is a fibrinogen receptor antagonist lacking the Arg-Gly-Asp sequence from the tick, Ornithodoros moubata.
TLDR
Disagregin is unique both in structure and function and may serve as a useful tool for the design of therapeutically useful antithrombotic agents. Expand
First Mesozoic Record of a Parasitiform Mite: a Larval Argasid Tick in Cretaceous Amber (Acari: Ixodida: Argasidae)
TLDR
Earlier hypotheses that Carios arose after the isolation of South America are challenged but not rejected by the discovery of this fossil, and Salvaging these hypotheses seems most compatible with dispersal on birds, an idea consistent with the presence of a small feather in the same outcrop in which the tick fossil was found. Expand
Comparative Hemostasis in Vertebrates
TLDR
The Alphabetical List of Animals: The Most Primitive Vertebrates and Comparative Families: Bleeding Times and Activated Partial Thromboplastin Times. Expand
The Adaptive Evolution Database (TAED)
TLDR
In TAED, potential examples of positive adaptation are identified by high values for the normalized ratio of nonsynonymous to synonymous nucleotide substitution rates on branches of an evolutionary tree between nodes representing reconstructed ancestral sequences. Expand
Selection in the evolution of gene duplications
TLDR
It is hypothesized that gene duplications that persist in an evolving lineage are beneficial from the time of their origin, due primarily to a protein dosage effect in response to variable environmental conditions; duplications are likely to give rise to new functions at a later phase of their evolution once a higher level of divergence is reached. Expand
The probability of duplicate gene preservation by subfunctionalization.
TLDR
The model proposed herein leads to quantitative predictions that are consistent with observations on the frequency of long-term duplicate gene preservation and with observations that indicate that a common fate of the members of duplicate-gene pairs is the partitioning of tissue-specific patterns of expression of the ancestral gene. Expand
...
1
2
3
...