The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

Abstract

The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is ‘dilution-fast’ under physiological conditions of transudation or pathological conditions of inflammation.

DOI: 10.1007/s007050050310

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Cite this paper

@article{Bolt1998TheIO, title={The influence of the milieu on the rate of neutralisation of herpes simplex virus 1}, author={C. E. Bolt and James Davies and Stephen Randall and G. R. B. Skinner}, journal={Archives of Virology}, year={1998}, volume={143}, pages={549-556} }