The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation.

A. L. Horne; P. C. Harkness; K. Hadingham; P. Whiting; J. Kemp

Corpus ID: 43561548

The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation.

@article{Horne1993TheIO,
  title={The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation.},
  author={A. L. Horne and P. C. Harkness and K. Hadingham and P. Whiting and J. Kemp},
  journal={British journal of pharmacology},
  year={1993},
  volume={108 3},
  pages={
          711-6
        }
}

A. L. Horne, P. C. Harkness, +2 authors J. Kemp

Published 1993

Medicine

British journal of pharmacology

1. Whole-cell patch clamp recordings were made from L-cells transfected with 2 combinations of subunits of the GABAA receptor. Log concentration-response curves were constructed to gamma-aminobutyric acid (GABA) on alpha 1,beta 1,gamma 2L containing cells and compared to those from alpha 1,beta 1 containing cells. The effects of flunitrazepam, pentobarbitone and alphaxalone on the concentration-response relationships were also examined. 2. From the log concentration-response curves, GABA had a… CONTINUE READING

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